Waterbirds, who must travel up to thousands of kilometres to complete their breeding cycles, are extremely vulnerable to changes in the environment.The publication, prepared for a meeting under way in Antananarivo, Madagascar, of the African-Eurasian Waterbird Agreement (AEWA), said that the figure is at an even higher 55 per cent in Western and Central Asia.Despite varying causes behind the decline in these populations, the most frequent source is habitat destruction and wetlands exploitation, both often spurred by unsustainable human activity, according to the report, which was supported by the UN, according to a press release issued by the UN Environment Programme (UNEP).Its findings are “a clear signal that both national and international efforts to conserve migratory waterbirds and their habitats need to be significantly increased,” said Bert Lenten, AEWA’s Executive Secretary. 16 September 2008Poorly planned economic development is at the root of the more than 40 per cent plunge in migratory waterbird populations travelling across Africa and Eurasia, according to a new United Nations-backed report issued today.
Quotations for key foreign currencies in terms of the Canadian dollar. Quotations are nominal, for information purposes only.Canadian dollar value on Thursday, the previous day, three-months and one-year: Currency Thu Wed 3 months Year U.S. dollar 1.2548 1.2479 1.2982 1.3182 British Pound 1.6476 1.6553 1.6774 1.6800 Japanese Yen 0.0111 0.0111 0.0115 0.0127 Euro in U.S. 1.1714 1.1762 1.1334 1.1205 Euro in Cdn 1.4699 1.4678 1.4714 1.4770Quotations provided by the Bank of Canada
CHICAGO — The Latest on a possible vaping-related illnesses around the U.S. (all times local):3:15 p.m.Health officials say the number of the number of severe breathing illnesses reported in people who vape has grown to nearly 200 in 22 states.Officials with the Centers for Disease Control and Prevention released the new figures Friday and confirmed that an adult in Illinois is being counted as the first death in the investigation.An Illinois official said the death was reported to the state Thursday but gave no other details.All of the illnesses were in teens or adults who had used an electronic cigarette or some other kind of vaping device. Doctors say the illnesses resemble an inhalation injury, with the lungs apparently reacting to a caustic substance.No single vaping product or compound has been linked to all of the cases. Officials say it’s not clear if there’s a common cause.___11:30 a.m.Illinois health officials are reporting what could be United States’ first death tied to vaping.In a Friday news release, the Illinois Department of Public Health says a person who recently vaped died after being hospitalized with “severe respiratory illness.” The agency didn’t give any other information about the patient, including a name or where the person lived.Melaney Arnold, an agency spokeswoman, says the death is the first in the state that could be linked to vaping. The release also says the number of people who have experienced respiratory illness after vaping doubled to 22 in the past week.In a Wednesday news release announcing 149 cases of severe lung illness nationwide that may be tied to vaping, the Centers for Disease Control and Prevention said no deaths associated with vaping had been reported.The Associated Press
In a statement on the results, which showed a majority approving the text, Secretary-General Kofi Annan’s Special Representative Ashraf Qazi pledged the continued readiness of the UN Assistance Mission in Iraq (UNAMI) and its electoral assistance team to help in the general elections scheduled for 15 December.”The results of the referendum have indicated the degree of political polarization in Iraq,” Mr. Qazi said. “This poses an ongoing challenge for all Iraqis and underscores the importance of an inclusive national dialogue.”Accordingly, it is essential that all of Iraq’s communities fully participate in the December elections to ensure their full representation in the Government, the Council of Representatives and the Constitutional Review Commission which will be established for the express purpose of further broadening the national base of support for the fundamental law of the land, i.e. the Constitution,” he added.In a statement issued by his spokesman in New York, Mr. Annan commended the Iraqi people for “this historic event” and hoped it would mark a milestone on Iraq’s path to democracy.”The high levels of voter turnout throughout the country and amongst all the main political constituencies are particularly encouraging,” he said. “That so many voters turned out to vote despite the threats against them is a welcome sign of their desire to choose ballots rather than bullets to express their political views.”He called on all Iraqis to participate with the same commitment in the upcoming election campaign.”The Secretary-General hopes that the adoption of Iraq’s constitution will encourage all Iraqis to reach out to one another in a spirit of national reconciliation through a fully inclusive political process to build a democratic and united Iraq,” the statement said. “The United Nations will continue to make every effort to support the efforts of the Iraqi people and Government to that end.”
The UN mission in Sudan (UNMIS) today strongly condemned Saturday’s attack on the African Union’s mission in that country, in which two soldiers were killed. In a statement issued in Khartoum, the spokesperson for UNMIS extended condolences to the African Union Mission in Sudan (AMIS) and to the families of the two soldiers killed by an unidentified group of armed men in the Kuma area of North Darfur. “UNMIS calls on all parties to the Darfur conflict to respect the neutral and impartial status of AMIS,” said the statement, which went on to recall that “any attack against the African Union personnel deployed in Darfur is a serious violation of international law, constitutes a breach of existing ceasefire agreements, and contravenes relevant resolutions of the United Nations Security Council.” The statement added that UNMIS supports the AMIS decision to carry out a thorough investigation to identify the perpetrators of the attack, urging all parties to fully cooperate in bringing those responsible to justice. Despite the signing of the Darfur Peace Agreement (DPA) in May, fierce fighting has continued in the region, and the number of attacks on humanitarian workers has recently soared to unprecedented levels. A draft resolution to replace AMIS with a UN peacekeeping operation is circulating among Security Council members, but the Sudanese Government says it opposes having blue helmets in Darfur.
Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedOPINION: Eyewitness – Jawboning…July 26, 2019In “latest news”EYEWITNESS: Tragedy…June 14, 2018In “EYEWITNESS”EYEWITNESS: Pappy show…May 24, 2017In “EYEWITNESS” …on elections riggingIt looks like folks are finally listening to your (barefoot) Eyewitness crying in the wilderness (so it seemed!) about the ground being laid for first delaying, and then rigging if necessary, the scheduled 2020 general elections. As he’d explained, the two-year delay – like the one from 1990 to 1992 – will ensure oil is flowing by then, and (hopefully) the good times are rolling.If, in fact, the latter scenario plays out, there will be no need to rig – whether with a scalpel or a sledge hammer. But crucial to everything is to drag out the elections. And as a Government filled with military types, they aren’t just rolling out a single plan. There are plans A, B, C and the entire alphabet drafted to handle all possible contingencies.In play right now is the “delay option” through foot dragging and digging in of heels on the GECOM Chairman. Apart from the mice playing with (and eating out) the cheese while the cat’s away, if a chairman isn’t found by 2020, then there will be no legitimised elections. Delaying the elections then becomes the ONLY option feasible, no?But we just heard about another delay option…which sounds even more convincing to your Eyewitness. It’s so good it could even be Option A. This is the “need for constitutional change” option. The international community – A,B,C,D and the whole alphabet soup of countries – has pronounced on the need for constitutional change. Seminars have been held. (Pliable) front groups have been formed to push the (fine) point. The Government insists it “believes” in constitutional change.The PM Minister’s even been allocated $80 million dollars for countrywide “consultations” on the subject – after a high-powered group held a year of hearings and came up with a raft (or a canoe) of proposals.A hint about this new “delay option” came when Pressie dismissed those proposals as being gathered behind four walls! He – a man who launches CoIs sitting within four walls at the drop of a beret – insisted the entire country must be canvassed! Presumably in open spaces. Hence the $80 million. But nothing’s been done since by the PM, and even though he’s no Speedy Gonzalez, the delay is ominous.So, at a high-powered gathering, the ex-chair of the AFC (who just happens to be the fella who led the “four walls” constitutional initiative) opined there ain’t no way consultations would be completed by 2020.His successor as AFC Chair, who just happens to be the Public Security Minister, stoutly asserted there ain’t no way he’s going to ALLOW any delays on elections.Really?? And exactly how will this be done? Holding his breath??…on tradeYour Eyewitness has been following the emanations from the Business Summit sponsored by our Private Sector. Foreign Affairs Minister Carl Greenidge, for instance, was on the critical panel on trade. Incidentally, this fella Greenidge takes his designation much too literally. Being a “Foreign” Minister doesn’t mean he has to be “foreign” all the time!! Or is it he and Pressie can’t be in the same hole at the same time??!!Anyhow, Greenidge moaned about us not breaking out of the traditional EIGHT primary products (he expanded on Pressie’s “six curses”) and wondered when our Private Sector would get its act together. But hold it! What about that Economic Partnership Agreement (EPA) he negotiated on behalf of CariCom with Europe? Wasn’t this supposed to ensure “value added” gets shipped to Europe?Jagdeo was upset with the deal, but Greenidge said “not to worry”!! Yeah right!!Incidentally, whatever happened to the big bucks that came via “Aid for Trade” to help the Private Sector add value??…on Police Top BrassIf one CoI’s delivering results, it’s the one into the alleged assassination plot against Pressie.The recommendation is to axe the entire top brass. So, is a sergeant to take over?Cause Ramjattan said, unlike TT, Guyana’s not looking foreign.
← Previous Story Metalurg with 7.000 fans waiting for HSV Next Story → AG Copenhagen’s owner, Kasi Jesper: We will win EHF CL next year! AG CopenhagenEHF Champions LeagueHC Partizan BelgradeJoachim Boldsen Legendary Danish playmaker, Joachim Boldsen – Traktor has to go “under the knife” since he has problem with a meniscus in his knee.– I have problems with the meniscus. Knee swollen, and it is something to be operated. But only in the summer when there is time. It’s nothing dangerous, but tease sometimes. And on Wednesday it was bad – says Boldsen, however, showed in the secure Champions League victory over Partizan Belgrade 29:23 that a few days break can do wonders.source: sporten.dk
Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 10 Nov 2015 – Seven years of work in the bushes has created a new nature trail experience in Middle Caicos which the crafters of it are calling, the Caicos Pine Yard Trail. Bryan Naqqi-Manco is the Caicos Pine Recovery Project Manager and he explains in the announcement issued yesterday that it is a .45 mile long trek, with 16 stopping points within a native pine yard. Bryan says it a new experience which unravels the life and habitat of the Caicos Pine, found primarily in Middle Caicos. “Each stopping point is related to the corresponding text in the trail guide brochure, providing an explanation about the plants, animals, habitat, threats and conservation measures. The trail can be self-guided (brochure available on site) or guided tours by local ecotourism companies and local guides can be arranged by contacting DEMA’s office in Providenciales.” The Caicos Pine is the national tree of the Turks and Caicos and it is listed in the IUCN Red List of threatened species as ‘vulnerable.’ Related Items:Bryan Naqqi-Manco, caicos pine, Caicos Pine Yard Trail, middle caicos, Nature Trail North to Middle Caicos Causeway behind schedule; residents concerned over Joaquin flooding Recommended for you PNP open North & Middle Caicos causeway in tribute Middle Caicos has a new man in charge Facebook Twitter Google+LinkedInPinterestWhatsApp
KUSI Newsroom Updated: 5:06 PM KUSI Newsroom, 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – Over the weekend the bridge that connects Normal Heights and Kensington was covered in racist graffiti. KUSI’s Dan Plante has more on the story. Racist bridge graffiti in Kensington and Normal Heights communities Categories: Local San Diego News FacebookTwitter July 29, 2019 Posted: July 29, 2019
NORTH MIAMI BEACH, FLA. (WSVN) – A construction worker had to be taken to the hospital after she was injured on the job, Monday.Officials said the worker tripped and fell at a construction site along Biscayne Boulevard and Northeast 163rd Street in North Miami Beach.Video shows fire crews inside the building taking the worker away on a stretcher and into an ambulance.The worker suffered a leg injury and was taken to a nearby hospital.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
$999 Daniel Craig returns as James Bond, 007 in… NO TIME TO DIE. Out in the UK on 3 April 2020 and 8 April 2020 in the US. #Bond25 #NoTimeToDie pic.twitter.com/qxYEnMhk2s— James Bond (@007) August 20, 2019 Recently updated to include digital-photo-frame capabilities, the Lenovo Smart Clock brings Google Assistant goodness to your nightstand. It’s a little smaller than the Amazon Echo Show 5, but also a full $30 less (and tied with Prime Day pricing) during this Best Buy Labor Day sale. $999 TV and Movies,I’m shocked — shocked! — to learn that stores are turning Labor Day into an excuse to sell stuff. Wait — no, I’m not. As much as I respect the original intent of the holiday (which became official back in 1894), to most of us, it’s just a bonus day off — one that’s blissfully tacked onto a weekend. So, yeah, stores; go ahead, run your sales. I’m listening. Perhaps unsurprisingly, Labor Day doesn’t bring out bargains to compete with the likes of Black Friday (which will be here before you know it), but there are definitely some sales worth your time.For example:We’ve rounded up the best Labor Day mattress deals.We’ve also gathered the best Labor Day laptop deals at Best Buy.Be sure to check out Amazon’s roughly three dozen Labor Day deals on TVs and audio. Google Express is having a big sale as well, one that includes deals on game consoles, AirPods, iPhones, laptops and more.Below I’ve rounded up a handful of individual items I consider to be the cream of the crop, followed by a handy reference guide to other Labor Day sales. Keep in mind, of course, that products may sell out at any time, even if the sale itself is still running. Note that CNET may get a share of revenue from the sale of the products featured on this page. HP Laptop 15t Value: $520 (save $780) 7 Apple AirPods with Wireless Charging Case: $155 (save $45) See It 4 A word about #BOND25 from Rami Malek pic.twitter.com/CLJ5mpO9mu— James Bond (@007) April 25, 2019 JBL Soundgear wearable speaker: $90 (save $160) Share your voice $999 $6 at Tidal DJI Osmo Action camera: $261 (save $89) Comments See It Amazon Lenovo 130-15AST 15.6-inch laptop: $210 (save $90) 16 Photos $520 at HP Apple iPhone XS Preview • iPhone XS is the new $1,000 iPhone X Sarah Tew/CNET I thought this might be a mistake, but, no, the weirdly named HP Laptop 15t Value is indeed quite the value at this price. Specs include an Intel Core i7 processor, 12GB of RAM, a 256GB solid-state drive and a 15.6-inch display. However, I strongly recommend paying an extra $50 to upgrade that display to FHD (1,920×1,080), because you’re not likely to be happy with the native 1,366×768 resolution. Sarah Tew/CNET Tags Lenovo Smart Clock: $59.99 (save $20) Sarah Tew/CNET Use promo code 19LABOR10 to get an unusually good deal on JBL’s interesting hybrid product — not quite headphones, and not quite a traditional speaker, but something you wear like neckphones to listen to music on the go. CNET may get a commission from retail offers. Google Nest Hub: $59 (save $70) Tags Sprint Aston Martin reveals James Bond-inspired DBS Superleggera $299 at Amazon Chris Monroe/CNET The Cheapskate Share your voice $155 at Google Express Spotify and most other streaming services rely on compressed audio, which robs the listener of full fidelity. Enter Tidal, the only “major” service that delivers lossless audio — meaning at least on par with CD quality, if not better. Want to see (er, hear) the difference for yourself? Grab this excellent extended trial while you can. It’s just $6 for three months, and it’s good for up to six listeners. Turo: Save $30 on any car rental Though not technically a Labor Day sale, it’s happening during Labor Day sale season — and it’s too good not to share. Nationwide Distributors, via Google Express, has just about the best AirPods deal we’ve seen (when you apply promo code ZBEDWZ at checkout). This is for the second-gen AirPods with the wireless charging case. Can’t imagine these will last long at this price, so if you’re interested, act fast. $59 at eBay Free Echo Dot with an Insignia or Toshiba TV (save $50) Sarah Tew/CNET Read the AirPods review See at Amazon Rylo 5.8K 360 Video Camera: $250 (save $250) Angela Lang/CNET Best laptops for college students: We’ve got an affordable laptop for every student. Best live TV streaming services: Ditch your cable company but keep the live channels and DVR. See It DJI’s answer to GoPro’s action cameras is rugged little model that’s shockproof, dustproof and waterproof down to 11 meters. It normally runs $350, but this deal drops it to $261 when you apply promo code 19LABOR10 at checkout. Boost Mobile TVs Speakers Mobile Accessories Cameras Laptops Automobiles Smart Speakers & Displays 007 will return. On Tuesday, the official James Bond Twitter account revealed that the 25th film in the super-spy series will be called No Time To Die. It’ll hit theaters on April 3, 2020, in the UK and April 8, 2020, in the US. Best Buy Other Labor Day sales you should check out Best Buy: In addition to some pretty solid MacBook deals that have been running for about a week already, Best Buy is offering up to 40% off major appliances like washers, dryers and stoves. There are also gift cards available with the purchase of select appliances. See it at Best BuyDell: Through Aug. 28, Dell is offering an extra 12% off various laptops, desktops and electronics. And check back starting Aug. 29 for a big batch of Labor Day doorbusters. See it at DellGlassesUSA: Aug. 29 – Sept. 3 only, you can save 65% on all frames with promo code labor65. See it at GlassesUSALenovo: The tech company is offering a large assortment of deals and doorbusters through Labor Day, with the promise of up to 56% off certain items — including, at this writing, the IdeaPad 730S laptop for $700 (save $300).See it at LenovoLensabl: Want to keep the frames you already love and paid for? Lensabl lets you mail them in for new lenses, based on your prescription. From now through Sept. 2 only, you can save 20% on the blue light-blocking lens option with promo code BLOCKBLUE. See it at LensablSears: Between now and Sept. 7, you can save up to 40% on appliances (plus an additional 10% if you shop online), up to 60% on mattresses, up to 50% on Craftsman products and more. The store is also offering some fairly hefty cashback bonuses. See it at SearsMore to come! Note: This post was published previously and is continuously updated with new information.CNET’s Cheapskate scours the web for great deals on tech products and much more. For the latest deals and updates, follow the Cheapskate on Facebook and Twitter. Questions about the Cheapskate blog? Find the answers on our FAQ page, and find more great buys on the CNET Deals page. Mentioned Above Apple iPhone XS (64GB, space gray) Read Google Home Hub review Read Lenovo Smart Clock review Rylo $999 What’s cooler: A snapshot of a firework exploding in front of you, or full 360-degree video of all the fireworks and all the reactions to seeing them? Oooh, ahhh, indeed. At $250, the compact Rylo dual-lens camera is selling for its lowest price yet. And for an extra $50, you can get the bundle that includes the waterproof housing.This deal runs through Sept. 3; it usually costs $500. $60 at Best Buy Formerly known as the Google Home Hub, Google’s Nest Hub packs a wealth of Google Assistant goodness into a 7-inch screen. At $59, this is within a buck of the best price we’ve seen. It lists for $129 and sells elsewhere in the $89-to-$99 range.This is one item of many available as part of eBay’s Labor Day Sale (which, at this writing, doesn’t specifically mention Labor Day, but that’s how it was pitched to us). Read DJI Osmo Action preview Read the Rylo camera preview $90 at Daily Steals via Google Express The problem with most entry-level laptops: They come with mechanical hard drives. That makes for a mighty slow Windows experience. This Lenovo model features a 128GB solid-state drive, so it should be pretty quick to boot and load software, even with its basic processor. Plus, it has a DVD-burner! That’s not something you see in many modern laptops, especially at this price. An Echo Dot makes a fine match for any Fire edition TV, because you can use the latter to say things like, “Alexa, turn on the TV.” Right now, the 24-inch Insignia Fire TV Edition starts at just $100, while the 32-inch Toshiba Fire TV Editions is on sale for $130. Just add any Fire TV Edition to your cart, then add a third-gen Echo Dot, and presto: The latter is free. Comments See it Tidal 3-month family subscription: $5.99 (save $54) $261 at Daily Steals via Google Express Review • iPhone XS review, updated: A few luxury upgrades over the XR Turo is kind of like Uber meets Airbnb: You borrow someone’s car, but you do all the driving. I’ve used it many times and found it a great alternative to traditional car-rental services — in part because you get to choose exactly the vehicle you want (not just, say, “midsize”) and in part because you can often do pickup and dropoff right outside baggage claim.Between now and Sept. 1, the first 300 people to check out can get $30 off any Turo rental with promo code LDW30. While it was known that Craig would be returning for one more go, there’s already been controversy about who will play Bond after he gives up the golden gun. There’s been talk that the role would pass to a woman or an actor of color, with Idris Elba denying that he’d take the role. Daniel Craig returns for his fifth turn as Bond. Some of the plot has already been revealed. The film begins with Bond vacationing in Jamaica before things turn dangerous. Oscar-winning actor Rami Malek plays the villain, and he’s already promised he won’t make it easy on Bond. Turo $210 at Best Buy See at Turo
Picture: A fuel tanker moves past Air India passenger jets parked at an airport in Kolkata. [Representational Image]Reuters fileMonsoon rains have caused many deaths in India but travellers are all set to boost the travel industry’s year-on-year growth. Airlines are therefore giving attractive offers on portals. “The traffic is being driven by airlines announcing sales in advance to stimulate early booking,” said Sharat Dhall, COO, B2C, Yatra.com. Yatra.com jumped 68 percent in airline bookings this monsoon season compared to last year. Hotel bookings surged more than 300 percent, Economic Times reported.Last week, Indigo Airlines had offered an all-inclusive fare of Rs 1,111 — valid from August 2 to August 6 across 45 domestic and international destinations.India’s most preferred travel season is summer. But the demand for monsoon travel has exceeded the summer travel demand. Rainfall in the country is two percent higher than the long period average (Year 1951-2000), according to a BNP Paribas report.”Year-on-year growth for monsoon travel has surpassed summer travel growth for this year. Average daily searches for airline bookings grew by 27 percent year-on-year for domestic and 15 percent for international destinations for monsoon travel. People are looking at heading out to relish the lush greens and rejuvenating spells of drizzle and rain evident from an overall 20 percent year on year increase in monsoon travel this year,” said Balu Ramachandran, head, air and distribution, Cleartrip.The top service-driven areas like New Delhi, Mumbai, Bengaluru, Hyderabad and Chennai have witnessed the maximum number of bookings for monsoon travel packages.
Photo via Alley Theatre Former Alley Theatre Artistic Director Gregory Boyd is now at the center of numerous misconduct allegations.More than a dozen current and former Alley Theatre employees allege the outgoing artistic director, Gregory Boyd, had created a toxic work atmosphere by singling out young actresses for verbal abuse.Boyd abruptly retired this week from the theatre after 28 years. The company’s tax records show Boyd was a year into a five-year contract and was paid at least $420,000 in fiscal year 2016.The allegations mainly focus on bullying and abusive behavior toward young women under Boyd’s direction on the stage, the Houston Chronicle reported. Emily Trask, a member of the theatre for nearly two years, said she quit the company in April after reporting that Boyd bullied her, called her vulgarities and twice touched her inappropriately.“I felt I had no choice but to leave what was my dream job,” she said to the Chronicle, citing “harassment and what I felt to be an unsafe environment.”The newspaper reports that Boyd hasn’t responded to its requests for comment and theater officials declined comment.A second actress, who was not identified for fear of retaliation, said Boyd pinched her buttocks once on stage and once while she was making coffee in a break room. “It was a very scary place to work for me,” she said, “a very hostile place.”The theater’s administrators and board president declined to answer questions about the allegations against Boyd. #MeToo comes to Houston: After Gregory Boyd’s abrupt resignation, Alley Theatre actors tell the inside story. https://t.co/Y8nJovpn9l pic.twitter.com/zH7RiJfEao— Lisa Gray (@LisaGray_HouTX) January 12, 2018 Share Did the #metoo movement force @AlleyTheatre’s hand in the retirement of Gregory Boyd? Explosive allegations on #abc13 at 6. pic.twitter.com/x58ZYvxxiQ— Miya Shay (@ABC13Miya) January 10, 2018 “He took away our voices and put us in our underwear.” More than a dozen current and former Alley Theatre employees say Gregory Boyd singled out young female actresses for verbal abuse. https://t.co/Fg4J76gUdb— Wei-Huan Chen (@weihuanchen) January 12, 2018___Information from: Houston Chronicle, http://www.houstonchronicle.com Alley Theatre could face challenges in replacing Gregory Boyd https://t.co/QTr9uw5uaZ via @HoustonChron— Katherine Feser (@kfeser) January 10, 2018
Listen at WEAA Live Stream: http://amber.streamguys.com.4020/live.m3uNational politics focusing on the chaotic Trump White House, with guest host, Kaye Wise Whitehead, author, public intellectual and professor at Loyola University MarylandThese stories and much more on AFRO’s First Edition with Sean Yoes, Monday through Friday, 5-7 p.m.
March 4 was a terrible Sunday for the members of venable Grace Memorial Baptist Church in East Baltimore, when a catastrophic 2-alarm fire erupted at the church located at 1100 N. Eden St. Congregants had been attending Sunday school at the time of the blaze. No one was injured.Historic Grace Memorial Baptist Church at 1100 N. Eden St., in East Baltimore, was destroyed by fire last Sunday. (Photo by Sean Yoes)Fire officials received calls about 10:30 a.m., about smoke coming from the roof of Grace Memorial, which was established in 1926 by Rev. Albert J. Greene and a few other members, who had been worshipping at each others homes. The church was first housed at the Star Theatre Auditorium on Monument St., before moving to the Eden St. location.There is no word yet on where the church will relocate temporarily.
Explore further This insufficient or otherwise laggy inhibition of behavior has been linked to genetic alterations in various components of inhibitory neural transmission. One protein implicated here is known as gephyrin, which comes from Greek for the word ‘bridge’. It’s presumed occupation in synapses is to cluster gaba and glycine receptors to each other, and to the cytoskeleton. A curious thing about gephyrin is that it moonlights in another critical, if sometimes enigmatic role: it sits at the apex of a complex molybdenum cofactor synthesis chain, and pops a single Mo ion into the molybdopterin backbone ultimately used in least four human enzymes.Lurking beneath this ostensibly more ancient Mo insertion skill of gephyrin is a more sweeping Mo culture that has only recently been uncovered. According to Michael Russell from NASA’s Jet Propulsion Lab, there may likely have been an ‘ineluctable requirement’ for this second-row transition metal, and perhaps its column VI tablemate tungsten, at the origin of life itself. As Mo is the heaviest essential element we require (significantly heavier than Fe), it isn’t bred in standard stellar fusion reactions. The nucleosynthesis of Mo occurs at much higher energies in rapidly spinning gas giants and supernova explosions. It may therefore be the case that not just the birth of our solar system, but life on Earth required the eclectic services that local supernova provide.But this noble birth isn’t what makes Mo crucial to life. To understand why our sulfite oxidase, xanthine oxidase, aldehyde oxidase, and mitochondrial amidoxime reductase keep Mo on retainer to this day, we need to take a brief foray into the world of metallochemistry, electron bifurcation, and redox potentials. The main task is to identify what functions, if any, which Mo can perform that no other biometal can. But before that it is necessary to show that Mo was available to life at its origin. In the bacterial world, Mo, vanadium, and tungsten enjoy some limited degree of interoperability as cofactors. There are over 40 Mo enzymes in prokaryotes, many times more than the few used in us. Workhorses like the nitrogenases, which handle nearly all the global cycling of nitrogen through the biosphere use a special iron-molbdenum cofactor to fix dinitrogen gas. The Complex-Iron-Sulfur-Molybdoenzyme (CISM) superfamily members, which include such dignitaries as the primordial ferredoxins, have ubiquitous, if varied roles among prokaryotes. Discovery suggests possible revolutionary antibiotics While tungsten is rare, it would have been available to early life in both acid and alkaline solutions. Mo, although it is roughly 100 times more abundant, presents more of a challenge due to its insolubility in reduced and neutral waters. As with copper enzymes, geochemists have tended to assume that Mo (and its molybdate oxide anions) would not have been available, or at least soluble until oxygen-creating photosynthesis came on the scene some 2.5 billion years ago. The question of Cu availability raises an interesting point which I asked Russell about. Namely, in order to crown the molydopterin cofactor with its Mo, how did it come to be that gephyrin needs to replace a Cu atom that was pre-bound at an earlier synthesis step?It is widely accepted that the primitive atmosphere, and by implication the primitive ocean, were strongly reducing due to abundant H2, CH4, and H2S. Russell’s solution to the Mo availability problem is that the founding ‘cradle-of-life’ CISM-catalyzed reactions mentioned above were supplied with Mo by alkaline hydrothermal vents. He and his colleagues were able to reconstruct an enzyme phylogeny using multiple 3D structural alignments to show a likely CISM superfamily origin well before the divergence of LUCA, the presumed last universal common ancestor.But what is it exactly, that Mo offers? Part of the versatility of the elements Mo and tungsten comes from the fact that they are 2-electron redox compounds—they can shuttle between the +4/+5 and the +5/+6 redox couples. In other words, they can perform diverse and energetically challenging redox reactions. Practically speaking, this means that they can act as an electron sink or source at low redox potential. Furthermore, they seem to be the only elements that can effectively transfer oxygen and sulfur atoms during reactions taking place at low potential.Recall that redox potential is simply a measure, typically in millivolts, of the tendency of chemical species to acquire electrons and thereby be reduced. A high positive redox potential electron acceptor accepts electrons more readily than one of low potential. Some CISM enzymes can participate in ‘crossed-over’ redox transitions, which were likely critical in early and energetically challenging reactions. These so-called ‘electron bifurcation’ phenomena (which we will delve into in more detail in the next post), are now known to play a central role in a wide range of metabolisms, not least being the Q cycle component of the electron transport chain in mitochondria.A recent paper in Current Opinion in Chemical Biology by Guenter Schwarz describes some of the more practical, modern day incidentals of the Mo world. Of note he has been looking for a way to address problems in sulfite oxidase deficiency. Normally this enzyme transforms undesirable sulfite to sulfate by passing electrons from sulfite sequentially to its MoCo (Mo cofactor), then to its haem cofactor, and then ultimately to its terminal acceptor, cytochrome c. For a patient that might have a malformed or ill-placed oxidase, Schwarz is working on a replacement enzyme which lacks the haem. In this case, the enzyme behaves like the plant version and passes its electron to a terminal molecular oxygen.It’s not just in normal metabolism of sulfur-containing amino acids like methionine and cysteine that sulfite oxidase is critical. The current use of sulfur dioxide in food preservation and winemaking persists today in an unbroken tradition dating back to the early Egyptians and Romans who used fumes from burning sulfur as a sanitizing agent. The uptake and transport proteins our bodies use to bring in Mo from the environment, and distribute to various compartments within the cell does a fair job of discriminating between the similar sized sulfate and molybdate ions. Without proper handling, excess sulfite can lead to severe reaction.Similarly, problems with the xanthine oxidase system (or its MoCo units), can disrupt the normal metabolism of certain nucleotides into uric acid. One interesting part of MoCo synthesis is that it all begins in the mitochondria using the nucleotide GTP. Various enzymes ‘cycle’ the GTP, transforming its ribose into part of the canonical pterin ring structure that is so ubiquitous to the cofactors favored by early metabolisms. Pterins, named for the Greek word ‘pteron’, meaning wing, were first discovered in the bright pigments of butterfly wings.As for the gephyrin problems we originally mentioned, and the ‘stiff man’ and related symptoms which can result, the jury is still out. It may seem now that the issue is entirely due to the synaptic functions; a result of errors in the various exon cassettes used to construct and target gephyrin to receptors, or to antibodies subsequently made against the protein. MoCo units don’t even seem to be made in neurons—culture studies show their synthesis only occurs in astrocytes. However, the story of how the MoCo protein that sits atop the synthetic pipeline came into its critical new synaptic organization role likely holds a few more secrets. One form of MoCo cofactor: the molybdopterin ring structure with its Mo ion More information: Guenter Schwarz, Molybdenum cofactor and human disease, Current Opinion in Chemical Biology (2016). DOI: 10.1016/j.cbpa.2016.03.016AbstractFour molybdenum-dependent enzymes are known in humans, each harboring a pterin-based molybdenum cofactor (Moco) in the active site. They catalyze redox reactions using water as oxygen acceptor or donator. Moco is synthesized by a conserved biosynthetic pathway. Moco deficiency results in a severe inborn error of metabolism causing often early childhood death. Disease-causing symptoms mainly go back to the lack of sulfite oxidase (SO) activity, an enzyme in cysteine catabolism. Besides their name-giving functions, Mo-enzymes have been recognized to catalyze novel reactions, including the reduction of nitrite to nitric oxide. In this review we cover the biosynthesis of Moco, key features of Moco-enzymes and focus on their deficiency. Underlying disease mechanisms as well as treatment options will be discussed. Citation: The jumping Frenchmen of Maine and the ineluctable requirement of molybdenum (2016, April 26) retrieved 18 August 2019 from https://phys.org/news/2016-04-frenchmen-maine-ineluctable-requirement-molybedenum.html © 2016 Phys.org (Phys.org)—The Jumping Frenchmen of Maine is a puzzling neurological syndrome named after a few peculiar 19th-century lumberjacks. Their defining symptom was an unnaturally exaggerated jumping reflex when startled. Georges Gilles de la Tourette included the disorder in his famous 1878 description of convulsive tic disorder, but to this day, its exact cause remains unknown. Among the many informative anecdotes associated with these particular French Canadians from Moosehead Lake, was that they could be inexplicably made to strike a dear loved one provided their agitator commanded it loudly enough. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
The Hong Kong Tourism Board (HKTB) recently concluded its India Travel Mission in Bengaluru, Mumbai, Kolkata and New Delhi. The mission witnessed the participation of more than 30 delegates representing Hong Kong’s top land operators, hoteliers, and popular attractions like Hong Kong Disneyland, Ngong Ping 360 Limited, Ocean Park Corporation, sky100 Hong Kong Observation Deck, Trickeye Museum Global Co Ltd.Key market agents not only from the four visiting cities, but also from Ahmedabad, Chennai, and Hyderabad joined the mission to strengthen their business ties with the Hong Kong trade representatives.The Travel Mission successfully served as a business networking platform for both Hong Kong and local trade partners to explore and collaborate for new business opportunities during their meetings.Harbour City sponsored the luncheons in all the cities during the session to help broaden the dynamic of shopping experience in Hong Kong.For the first seven months of 2016, over 296,000 visitor arrivals from India visited Hong Kong. With direct flights and fabulous and dynamic Hong Kong experiences for travellers, Hong Kong continues to see beneficial opportunities from the second fastest growing outbound market in the world.
By Stelios OrphanidesEconomic sentiment in Cyprus fell 0.2 units to 103.7 in March compared to the previous month, mainly on worsening confidence in the retail trade and among consumers, the University of Cyprus said.You May LikeLivestlyChip And Joanna’s $18M Mansion Is Perfect, But It’s The Backyard Everyone Is Talking AboutLivestlyUndoPopularEverythingColorado Mom Adopted Two Children, Months Later She Learned Who They Really ArePopularEverythingUndoYahoo SearchYou’ve Never Seen Luxury Like This On A Cruise Ship. Search Luxury Mediterranean CruisesYahoo SearchUndo Pensioner dies after crash on Paphos-Polis roadUndoCruise passenger airlifted to Paphos hospitalUndoRemand for pair in alleged property fraud (Updated)Undoby Taboolaby Taboola
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